Does changing post title effect SEO?

[Autofresh.in]

before you change the Title completely, don't forget to take the backup of last title description which are ranking pretty well. so in case if the new changes don't improve ranking you can revert the title description to the previous one.

I've got a post that ranks pretty well, but the title of it is a bit odd, I was wondering if its going to hurt my SEO if I were to change the title completely? I mean I'd leave the targeted keywords in it but it will be different!